R-Symmetry and the Topological Twist of N=2 Effective Supergravities of Heterotic Strings

We discuss R-symmetries in locally supersymmetric N=2 gauge theories coupled to hypermultiplets which can be thought of as effective theories of heterotic superstring models. In this type of supergravities a suitable R-symmetry exists and can be used to topologically twist the theory: the vector multiplet containing the dilaton-axion field has different R-charge assignments with respect to the other vector multiplets. Correspondingly a system of coupled instanton equations emerges, mixing gravitational and Yang--Mills instantons with triholomorphic hyperinstantons and axion-instantons. For the tree-level classical special manifolds $ST(n)=SU(1,1)/U(1)\times SO(2,n)/(SO(2)$ $\times SO(n))$ R-symmetry with the specified properties is a continuous symmetry, but for the quantum corrected manifolds ${\hat {ST}}(n)$ a discrete R--group of electric--magnetic duality rotations is sufficient and we argue that it exists.Comment: 40 pages, plain LaTeX. Final version to appear on IJMP

Adaptive implementation of turbo multi-user detection architecture

MULTI-access techniques have been adopted widely for communications in underwater acoustic channels, which present many challenges to the development of reliable and practical systems. In such an environment, the unpredictable and complex ocean conditions cause the acoustic waves to be affected by many factors such as limited bandwidth, large propagation losses, time variations and long latency, which limit the usefulness of such techniques. Additionally, multiple access interference (MAI) signals and poor estimation of the unknown channel parameters in the presence of limited training sequences are two of the major problems that degrade the performance of such technologies. In this thesis, two different single-element multi-access schemes, interleave division multiple access (IDMA) and code division multiple access (CDMA), employing decision feedback equalization (DFE) and soft Rake-based architectures, are proposed for multi-user underwater communication applications. By using either multiplexing pilots or continuous pilots, these adaptive turbo architectures with carrier phase tracking are jointly optimized based on the minimum mean square error (MMSE) criterion and adapted iteratively by exchanging soft information in terms of Log-Likelihood Ratio (LLR) estimates with the single-user’s channel decoders. The soft-Rake receivers utilize developed channel estimation and the detection is implemented using parallel interference cancellation (PIC) to remove MAI effects between users. These architectures are investigated and applied to simulated data and data obtained from realistic underwater communication trials using off-line processing of signals acquired during sea-trials in the North Sea. The results of different scenarios demonstrate the penalty in performance as the fading induces irreducible error rates that increase with channel delay spread and emphasize the benefits of using coherent direct adaptive receivers in such reverberant channels. The convergence behaviour of the detectors is evaluated using EXIT chart analyses and issues such as the adaptation parameters and their effects on the performance are also investigated. However, in some cases the receivers with partial knowledge of the interleavers’ patterns or codes can still achieve performance comparable to those with full knowledge. Furthermore, the thesis describes implementation issues of these algorithms using digital signal processors (DSPs), such as computational complexity and provides valuable guidelines for the design of real time underwater communication systems.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

A Search for Non-Perturbative Dualities of Local N=2N=2 Yang--Mills Theories from Calabi--Yau Threefolds

The generalisation of the rigid special geometry of the vector multiplet quantum moduli space to the case of supergravity is discussed through the notion of a dynamical Calabi--Yau threefold. Duality symmetries of this manifold are connected with the analogous dualities associated with the dynamical Riemann surface of the rigid theory. N=2 rigid gauge theories are reviewed in a framework ready for comparison with the local case. As a byproduct we give in general the full duality group (quantum monodromy) for an arbitrary rigid $SU(r+1)$ gauge theory, extending previous explicit constructions for the $r=1,2$ cases. In the coupling to gravity, R--symmetry and monodromy groups of the dynamical Riemann surface, whose structure we discuss in detail, are embedded into the symplectic duality group $\Gamma_D$ associated with the moduli space of the dynamical Calabi--Yau threefold.Comment: Latex. Version of previous paper with enlarged and revised appendix 35 pages, plain LaTe

Radioterapia intraoperatoria nei tumori maligni avanzati estesi all’orecchio medio: valutazione da uno studio retrospettivo

Obiettivo dello studio è stato quello di valutare la sicurezza, l’efficacia e i risultati funzionali della radioterapia intraoperatoria (IORT) seguita dalla radioterapia a intensità modulata (IMRT) nel trattamento di tumori maligni avanzati estesi all’orecchio medio. Sono stati inclusi nello studio in modo retrospettivo 13 pazienti consecutive affetti da tumore dell’orecchio esterno esteso all’orecchio medio. Il follow-up è stato in media di 33 mesi (range 6-133). Cinque pazienti (38%) erano di stadio III e 8 pazienti (62%) erano di stadio IV secondo la classificazione dell’Università di Pittsburgh. Una petrosectomia laterale (LTBR) è stata eseguita in tutti i pazienti, la LTBR è stata associata a parotidectomia in 5 (38%) casi e a svuotamento latero-cervicale associato a parotidectomia in 6 (46%) casi. In tutti i casi si è effettuata asportazione della malattia macroscopicamente evidente. Il trattamento chirurgico è stato completato da IORT (12 Gy) e IMRT (50Gy). Chemioterapia adiuvante è stata eseguita in 4 (30%) casi. Test audiometrici pre- e post-operatori sono stati eseguiti per valutare la perdita uditiva. Il tasso di controllo di malattia locale (LC) a 5 anni, di metastasi a distanza (DM) a 5 anni, la sopravvivenza libera da malattia (DFS) e la sopravvivenza globale (OS) a 5 anni sono state calcolate con il metodo di Kaplan-Meyer. Variazioni significative nella conduzione per via ossea sono state osservate dopo trattamento. Una necrosi parziale del lembo di ricostruzione è stata l’unica complicanza precoce osservata in 3(23%) casi, mentre una fistola meningea è stata osservata in un solo caso (7,6%) come complicanza tardiva. Il tasso di LC è stato del 68%. Il tasso di DM è stato del 90%. Il tasso di DFS è stato del 61%. Il tasso di OS è stato del 69%. La IORT seguita dalla IMRT nel trattamento dei tumori maligni avanzati dell’orecchio esterno e medio sembra essere sicuro. Nel nostro studio non sono riportati morti. La IORT può ridurre la dose di radioterapia postoperatoria a livello del tessuto residuo ottenendo la medesima dose a livello della sede del tumore. Non abbiamo osservato alcuna complicanza a livello dell’orecchio esterno residuo, mentre si è notato un peggioramento dell’udito anche a livello neurosensoriale. Sono necessari studi prospettici al fine di confermare quanto da noi osservato

Assessing performance of quantum annealing with non-linear driving

Current generation quantum annealers have already proven to be successful problem-solvers. Yet, quantum annealing is still very much in its infancy, with suboptimal applicability. For instance, to date it is still an open question which annealing protocol will universally cause the fewest diabatic excitations, and even whether there is a universally optimal strategy. Therefore, in the present work, we report analytical and numerical studies of the diabatic excitations arising from non-linear protocols applied to the transverse field Ising chain, the exactly solvable model that serves as quantum annealing playground. Our analysis focuses on several driving schemes that inhibit or facilitate the dynamic phases discussed in a previous work. Rather remarkably, we find that the paradigmatic Kibble-Zurek behavior can be suppressed with "pauses" in the evolution, both for crossing and stopping at the quantum critical point of the system

Identification of possible targets of the Aspergillus fumigatus CRZ1 homologue, CrzA

<p>Abstract</p> <p>Background</p> <p>Calcineurin, a serine/threonine-specific protein phosphatase, plays an important role in the control of cell morphology and virulence in fungi. Calcineurin regulates localization and activity of a transcription factor called CRZ1. Recently, we characterize <it>Aspergillus fumigatus CRZ1 </it>homologue, AfCrzA. Here, we investigate which pathways are influenced by <it>A. fumigatus </it>AfCrzA during a short pulse of calcium by comparatively determining the transcriptional profile of <it>A. fumigatus </it>wild type and <it>ΔAfcrzA </it>mutant strains.</p> <p>Results</p> <p>We were able to observe 3,622 genes modulated in at least one timepoint in the mutant when compared to the wild type strain (3,211 and 411 at 10 and 30 minutes, respectively). Decreased mRNA abundance in the <it>ΔcrzA </it>was seen for genes encoding calcium transporters, transcription factors and genes that could be directly or indirectly involved in calcium metabolism. Increased mRNA accumulation was observed for some genes encoding proteins involved in stress response. AfCrzA overexpression in <it>A. fumigatus </it>increases the expression of several of these genes. The deleted strain of one of these genes, AfRcnA, belonging to a class of endogenous calcineurin regulators, calcipressins, had more calcineurin activity after exposure to calcium and was less sensitive to menadione 30 μM, hydrogen peroxide 2.5 mM, EGTA 25 mM, and MnCl₂25 mM. We constructed deletion, overexpression, and GFP fusion protein for the closely related <it>A. nidulans </it>AnRcnA. GFP::RcnA was mostly detected along the germling, did not accumulate in the nuclei and its location is not affected by the cellular response to calcium chloride.</p> <p>Conclusion</p> <p>We have performed a transcriptional profiling analysis of the <it>A. fumigatus ΔAfcrzA </it>mutant strain exposed to calcium stress. This provided an excellent opportunity to identify genes and pathways that are under the influence of AfCrzA. AfRcnA, one of these selected genes, encodes a modulator of calcineurin activity. Concomitantly with <it>A. fumigatus AfrcnA </it>molecular analysis, we decided to exploit the conserved features of <it>A. nidulans </it>calcineurin system and investigated the <it>A. nidulans </it>AnRcnA homologue. <it>A. nidulans </it>AnRcnA mutation is suppressing CnaA mutation and it is responsible for modulating the calcineurin activity and mRNA accumulation of genes encoding calcium transporters.</p

The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress

The MRE11/RAD50/NBS1 (MRN) complex is a major sensor of DNA double strand breaks, whose role in controlling faithful DNA replication and preventing replication stress is also emerging. Inactivation of the MRN complex invariably leads to developmental and/or degenerative neuronal defects, the pathogenesis of which still remains poorly understood. In particular, NBS1 gene mutations are associated with microcephaly and strongly impaired cerebellar development, both in humans and in the mouse model. These phenotypes strikingly overlap those induced by inactivation of MYCN, an essential promoter of the expansion of neuronal stem and progenitor cells, suggesting that MYCN and the MRN complex might be connected on a unique pathway essential for the safe expansion of neuronal cells. Here, we show that MYCN transcriptionally controls the expression of each component of the MRN complex. By genetic and pharmacological inhibition of the MRN complex in a MYCN overexpression model and in the more physiological context of the Hedgehog-dependent expansion of primary cerebellar granule progenitor cells, we also show that the MRN complex is required for MYCN-dependent proliferation. Indeed, its inhibition resulted in DNA damage, activation of a DNA damage response, and cell death in a MYCN- and replication-dependent manner. Our data indicate the MRN complex is essential to restrain MYCN-induced replication stress during neural cell proliferation and support the hypothesis that replication-born DNA damage is responsible for the neuronal defects associated with MRN dysfunctions.Cell Death and Differentiation advance online publication, 12 June 2015; doi:10.1038/cdd.2015.81